Pregnancy is by some considered a contraindication for laparoscopic cholecystectomy. However, no evidence exists to support this opinion. We describe herein a laparoscopic cholecystectomy in a pregnant woman in the 22nd week of gestation with an uneventful postoperative recovery and normal completion of pregnancy. Laparoscopic cholecystectomy can be performed during pregnancy with a slight modification of the operative technique and is less traumatic than open surgery.