Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma
- 1 December 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 306 (5945), 760-765
- https://doi.org/10.1038/306760a0
Abstract
The nucleotide sequence of a translocated c-myc gene in a Burkett lymphoma [human Raji cells] reveals multiple base changes in the coding region. Twenty-five base changes, generating 16 codon alterations, were found in the 1st coding exon; no changes occur in the 2nd coding exon. These changes are probably the result of somatic mutations that occurred during and after translocation and may contribute to oncogenesis by allowing synthesis of an altered c-myc gene product.Keywords
This publication has 30 references indexed in Scilit:
- Translocation joins c-myc and immunoglobulin γ1 genes in a Burkitt lymphoma revealing a third exon in the c-myc oncogeneNature, 1983
- Two human c-onc genes are located on the long arm of chromosome 8.Proceedings of the National Academy of Sciences, 1982
- Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.Proceedings of the National Academy of Sciences, 1982
- Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.Proceedings of the National Academy of Sciences, 1982
- Localization of human immunoglobulin kappa light chain variable region genes to the short arm of chromosome 2 by in situ hybridization.Proceedings of the National Academy of Sciences, 1982
- Transcripts from the Cellular Homologs of Retroviral Oncogenes: Distribution Among Chicken TissuesMolecular and Cellular Biology, 1982
- Assignment of the genes for human λ immunoglobulin chains to chromosome 22Nature, 1981
- Cytogenetic studies on African Burkitt's lymphoma cell lines: t(8;14), t(2;8) and t(8;22) translocationsCancer Genetics and Cytogenetics, 1981
- Chromosomal location of the genes for human immunoglobulin heavy chains.Proceedings of the National Academy of Sciences, 1979
- Marker Band in One Chromosome 14 from Burkitt LymphomasNature, 1972