Sialic acids of human large bowel mucosa: o-acylated variants in normal and malignant states.
Open Access
- 1 July 1978
- Vol. 19 (7), 587-592
- https://doi.org/10.1136/gut.19.7.587
Abstract
Five sialic acid variants have been demonstrated in normal, 'transitional', and tumour extracts of human large bowel mucosa by thin-layer chromatography. Two-dimensional thin-layer chromatography, with intermediate alkaline hydrolysis, confirmed that the variants were N-acetyl neuraminic acids with additional O-acylation. Cases studied so far show changes in the proportions of these variants in malignancy.Keywords
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