"Dietary Factor" in Necrotizing Arteritis in Dogs a Lipid Substance.

Abstract

Previous work had shown that arterial lesions can be produced with regularity in dogs by controlling diet and kidney damage. By halving, doubling, and omitting the various ingredients of the "standard diet" (liver, sugar, starch, butter, cod liver oil, and tomato juice) which was being fed at the time these unanticipated lesions were first observed, the "dietary factor" was narrowed to a lipid substance contained in, but not unique to, cod liver oil; this factor had to be fed for 2 mos. or longer and manifested itself only following kidney damage. Further expts. showed that the factor is heat stable, is not readily oxidized, is not vit. A or D.