Ankylosing Spondylitis in a Large Kindred: Clinical and Genetic Studies
- 1 March 1975
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 5 (3), 205-212
- https://doi.org/10.1111/j.1399-0039.1975.tb01215.x
Abstract
In a kindred of 66 members spanning four generations, seven cases of ankylosing spondylitis (AS) HAVE BEEN FOUND. Four of these were in a single sibship of 13. AS was associated with HL-A27 in three of the four involved siblings, but close linkage was shown to be unlikely. Knowledge of HL-A genotype has made possible informed counseling for younger members of the sibship of 13, some of whom, as teenagers, already have back pain.Keywords
This publication has 22 references indexed in Scilit:
- HL-A27 IN ACUTE AND CHRONIC UVEITISThe Lancet, 1974
- REITER'S DISEASE AND HL-A 27The Lancet, 1973
- Sacroiliitis and ankylosing spondylitis in North American Indians.Annals Of The Rheumatic Diseases, 1972
- Histocompatibility-Linked Immune Response GenesScience, 1972
- Normal range of spinal mobility. An objective clinical study.Annals Of The Rheumatic Diseases, 1971
- An Appraisal of the Medical and Surgical Management of Ankylosing SpondylitisPublished by Wolters Kluwer Health ,1968
- Genetics of ankylosing spondylitis.Journal of Medical Genetics, 1967
- Hereditary Factors in Rheumatoid Arthritis and Ankylosing SpondylitisAnnals Of The Rheumatic Diseases, 1961
- Ankylosing Spondylitis in two Families Showing Involvement of Female Members Only: With a Search for Linkage to Genes Determining Blood Group AntigensScandinavian Journal of Rheumatology, 1960