A TISSUE FACTOR INFLUENCING SUCCINIC DEHYDROGENASE ACTIVITY IN TUBERCULOUS GUINEA PIGS
Open Access
- 1 June 1955
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 101 (6), 639-646
- https://doi.org/10.1084/jem.101.6.639
Abstract
The alterations in succinic-dehydrogenase activity during the course of infection with Mycobacterium tuberculosis strains H37Rv and BCG, as well as with dead bacilli, were described. A tissue factor was described which is prepared from normal bovine kidney and will restore enzyme activity in vitro. This factor is prepared by chromatographic analysis and contains a nucleotide with an UV absorption maxima at 250 mu (pH 3) and a free sulfhydryl group. The role of this factor in the response to tuberculosis is discussed.Keywords
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