Mutagenicity of a Monofunctional Alkylating Agent Derivative of Acridine in Neurospora
- 12 February 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 147 (3659), 750-751
- https://doi.org/10.1126/science.147.3659.750
Abstract
Purple adenine (ad-3) mutants induced in Neurospora crassa by 2-methoxy-6-chloro-9-(3-[ethyl-2-chloroethyl] aminopropylamino) acridine dihydrochloride (ICR-170) result from intragenic alterations. They are further characterized by low frequencies of leakiness, allelic complementation, and nonpolarized complementation patterns. These characteristics distinguish them from ad-3 mutants induced by x-rays, nitrous acid, and 2-aminopurine.Keywords
This publication has 15 references indexed in Scilit:
- Mutagenesis with light and proflavine in phage T4Genetics Research, 1964
- Induction of mutation by photodynamic action inEscherichia coliGenetics Research, 1964
- The Recent Excitement in the Coding ProblemProgress in Nucleic Acid Research and Molecular Biology, 1963
- General Nature of the Genetic Code for ProteinsNature, 1961
- Mono- and Difunctional Analogs of Some Quinoline and Acridine Nitrogen Mustards1The Journal of Organic Chemistry, 1961
- Structural considerations in the interaction of DNA and acridinesJournal of Molecular Biology, 1961
- A Direct Method for Determination of Forward-Mutation Rates in Neurospora crassaNature, 1958
- Recombination and Interference in the ad-3 Region of Neurospora crassaCold Spring Harbor Symposia on Quantitative Biology, 1958
- Chromosome Alteration and Tumour Inhibition by Nitrogen Mustards: the Hypothesis of Cross-linking AlkylationNature, 1950