d‐α‐Tocopherol inhibits low density lipoprotein induced proliferation and protein kinase C activity in vascular smooth muscle cells
Open Access
- 17 May 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 322 (3), 307-310
- https://doi.org/10.1016/0014-5793(93)81592-n
Abstract
Native and malondialdehyde modified low density lipoproteins have been shown to stimulate smooth muscle cell proliferation (A7r5) in vitro. The stimulation is associated with an increase of protein kinase C activity. d‐α‐Tocopherol, at physiological concentrations, has been found to inhibit both protein kinase C activity and cell proliferation.Keywords
This publication has 18 references indexed in Scilit:
- Smooth muscle cells and the pathogenesis of the lesions of atherosclerosisHeart, 1993
- Role of oxidised low density lipoprotein in atherogenesisHeart, 1993
- Phosphoinositide and calcium signalling responses in smooth muscle cells: Comparison between lipoproteins, Ang II, and PDGFBiochemical and Biophysical Research Communications, 1992
- Cell-transforming potential of low-density lipoproteinsCarcinogenesis: Integrative Cancer Research, 1992
- The protein kinase C familyEuropean Journal of Biochemistry, 1992
- Native and oxidized LDL enhances production of PDGF AA and the surface expression of PDGF receptors in cultured human smooth muscle cells.Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1992
- Oxidized low density lipoproteins stimulate phosphoinositide turnover in cultured vascular smooth muscle cells.Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1992
- Low- and high-density lipoproteins as hormonal regulators of platelet, vascular endothelial and smooth muscle cell interactionsJournal Of Hypertension, 1991
- Adrenergic and muscarinergic receptorsJournal Of Hypertension, 1991
- Modification of human serum low density lipoprotein by oxidation — Characterization and pathophysiological implicationsChemistry and Physics of Lipids, 1987