Differential expression of two sodium channel subtypes in human brain
- 25 May 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 303 (1), 53-58
- https://doi.org/10.1016/0014-5793(92)80476-w
Abstract
Two partial human brain sodium channel cDNA sequences (designated HBSC I and II) have been cloned and mapped to chromosome 2q23–2q24 by chromosome microdissection-PCR (CMPCR). The distribution of HBSC I and II mRNA in human brain was studied by means of a novel approach based on the ligase detection reaction. These studies demonstrate that HBSC I and II mRNA is heterogeneously distributed in brain. and that the relative ratio or the two forms can vary as much as 7-fold between different regions.Keywords
This publication has 26 references indexed in Scilit:
- Three brain sodium channel α-subunit genes are clustered on the proximal segment of mouse chromosome 2Genomics, 1991
- Assignment of a human skeletal muscle sodium channel α-subunit gene (SCN4A) to 17q23.1–25.3Genomics, 1991
- Misuse of PCRTrends in Biochemical Sciences, 1990
- Primary structure and expression of a sodium channel characteristic of denervated and immature rat skeletal muscleNeuron, 1990
- Primary structure and functional expression of a mammalian skeletal muscle sodium channelNeuron, 1989
- A rat brain na+ channel α subunit with novel gating propertiesNeuron, 1988
- Primary structure of rat brain sodium channel III deduced from the cDNA sequenceFEBS Letters, 1988
- Genomic Organization and Deduced Amino Acid Sequence of a Putative Sodium Channel Gene in DrosophilaScience, 1987
- Existence of distinct sodium channel messenger RNAs in rat brainNature, 1986
- Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating.The Journal of general physiology, 1981