Building epithelial architecture: insights from three-dimensional culture models
Top Cited Papers
- 1 July 2002
- journal article
- review article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 3 (7), 531-537
- https://doi.org/10.1038/nrm859
Abstract
How do individual cells organize into multicellular tissues? Here, we propose that the morphogenetic behaviour of epithelial cells is guided by two distinct elements: an intrinsic differentiation programme that drives formation of a lumen-enclosing monolayer, and a growth factor-induced, transient de-differentiation that allows this monolayer to be remodelled.Keywords
This publication has 62 references indexed in Scilit:
- Leaving the neighborhood: molecular mechanisms involved during epithelial‐mesenchymal transitionBioEssays, 2001
- Influence of microenvironment on mammary epithelial cell survival in primary cultureJournal of Cellular Physiology, 1999
- Bcl-2 overexpression prevents apoptosis-induced Madin-Darby canine kidney simple epithelial cyst formationKidney International, 1999
- Membrane Type 1-Matrix Metalloproteinase Is Involved in the Formation of Hepatocyte Growth Factor/Scatter Factor-Induced Branching Tubules in Madin-Darby Canine Kidney Epithelial CellsBiochemical and Biophysical Research Communications, 1998
- Origins of Cell PolarityCell, 1996
- Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development.The Journal of cell biology, 1993
- Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factorCell, 1991
- Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factorsCell, 1991
- Exocytosis of vacuolar apical compartment (VAC): a cell-cell contact controlled mechanism for the establishment of the apical plasma membrane domain in epithelial cells.The Journal of cell biology, 1988
- Polarity reversal of inside‐out thyroid follicles cultured within collagen gel: reexpression of specific functionsBiology of the Cell, 1984