Modification of Tumor-Response to Rous Sarcoma Virus (RSV) by Hydrocortisone.

Abstract

When RSV was inoculated into chicks pretreated with large doses of hydrocortisone the tumors appeared later and were greatly altered in appearance, being sharply circumscribed, firm, whitish, and growing more slowly than control tumors. When hydrocortisone was discontinued the altered tumors promptly reverted to typically soft and invasive tumors. When lower doses of hydrocortisone were employed or when injections were begun after inoculation of RSV the tumors were typically invasive and grew more rapidly than the controls.