Levodopa-Induced Dyskinesias
- 1 November 1973
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 29 (5), 328-330
- https://doi.org/10.1001/archneur.1973.00490290068008
Abstract
The incidence of levodopa-induced dyskinesias in 20 Guamanian patients with parkinsonism-dementia (PD) was compared with that found in 14 Guamanians with amyotrophic lateral sclerosis (ALS), who were matched for dose and duration of drug exposure. While 55% of the PD patients developed abnormal involuntary movements during the first six months of treatment, none of the ALS patients manifested this complication. In PD patients no definite correlation could be documented between pretreatment parkinsonian severity or degree of response to levodopa and the appearance of dyskinesias. The results suggest that lesions of the type which produce Parkinson disease increase the susceptibility to levodopa-induced dyskinesias, but that apparently denervation supersensitivity alone does not account for this phenomenon.Keywords
This publication has 15 references indexed in Scilit:
- Spontaneous Oral-Facial DyskinesiaArchives of Neurology, 1972
- Methyldopahydrazine as an adjunct to L‐dopa therapy in parkinsonismNeurology, 1972
- Effect of L-Dopa on the Locomotor Activity of Rats pretreated with 6-HydroxydopamineNature New Biology, 1971
- Parkinsonism‐dementia of GuamNeurology, 1971
- Analysis of L-dopa induced dyskinesias in 51 patients with ParkinsonismJournal of Neurology, Neurosurgery & Psychiatry, 1971
- The choreoathetoid movement disorder induced by levodopaClinical Pharmacology & Therapeutics, 1971
- A Study of Facial Dyskinesia in a Mental Hospital PopulationThe British Journal of Psychiatry, 1971
- LONG-TERM SIDE-EFFECTS OF LEVODOPAThe Lancet, 1971
- The Significance of Brain Damage in Persistent Oral DyskinesiaThe British Journal of Psychiatry, 1970
- Tardive Dyskinesia in Patients Treated with Major Neuroleptics: A Review of the LiteratureAmerican Journal of Psychiatry, 1968