Spatial Autocorrelations of HLA Frequencies in Europe Support Demic Diffusion of Early Farmers

Abstract

Allel frequencies (21) of the human HLA loci from 58 localities in Europe and the Near East were subjected to spatial autocorrelation analysis. The frequencies were significantly heterogeneous over the localities. Significant clinical structure is shown by most allel frequencies. Collective study of the 21 variable surfaces and of their correlograms supports a hypothesis of migration leading to the observed patterns with 3 alternative explanatory hypotheses being eliminated. Cluster analysis of allele frequency surfaces and of correlograms shows there are at least 3 distinct classes of patterns. Connecting localities along the established paths of the spread of the spread of agriculture into Europe shows that one of these surface clusters and their corresponding correlograms closely relate to the spread of farming. The results are compatible with a hypothesis of demic diffusion of early farmers into the hunter-gatherer population of Neolithic Europe first advanced by Ammerman and Cavalli-Sforza and corroborates by a different technique the evidence presented for this hypothesis by Menozzi et al.