Monoamine oxidase and aldehyde dehydrogenase activity in the striatum of rats after 6-hydroxydopamine lesion of the nigrostriatal pathway
Open Access
- 1 May 1973
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 48 (1), 175-178
- https://doi.org/10.1111/j.1476-5381.1973.tb08238.x
Abstract
Monoamine oxidase and aldehyde dehydrogenase activity were significantly reduced in the striatum of rats 8 days after lesion of the nigrostriatal nerve pathway caused by 6-hydroxydopamine. Evidence is presented for the existence of an intraneuronal 'dopamine monoamine oxidase' and intraneuronal aldehyde dehydrogenase. Dopamine concentrations were reduced to 10% of their control values.Keywords
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