Acute Elevations of Plasma Asymmetric Dimethylarginine and Impaired Endothelial Function in Response to a High-Fat Meal in Patients With Type 2 Diabetes
- 1 September 2000
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 20 (9), 2039-2044
- https://doi.org/10.1161/01.atv.20.9.2039
Abstract
—Asymmetric dimethylarginine (ADMA), a compound detectable in human plasma, is an endogenous inhibitor of NO synthase. Endothelial dysfunction is an early event in atherogenesis, and large-...Keywords
This publication has 25 references indexed in Scilit:
- Morning attenuation of endothelium‐dependent, flow‐mediated dilation in healthy young men: Possible connection to morning peak of cardiac events?Clinical Cardiology, 1999
- Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitusJournal of the American College of Cardiology, 1996
- Elevatedl-Arginine/Dimethylarginine Ratio Contributes to Enhanced Systemic NO Production by Dietaryl-Arginine in Hypercholesterolemic RabbitsBiochemical and Biophysical Research Communications, 1996
- Supplementation of hypercholesterolaemic rabbits with L-arginine reduces the vascular release of superoxide anions and restores NO productionAtherosclerosis, 1995
- Long-term inhibition of NO synthesis promotes atherosclerosis in the hypercholesterolemic rabbit thoracic aorta. PGH2 does not contribute to impaired endothelium-dependent relaxation.Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1994
- Synthesis of NG, NGDimethylarginine by Human Endothelial CellsEndothelium, 1993
- Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit.JCI Insight, 1992
- Large coronary arteries in humans are responsive to changing blood flow: An endothelium-dependent mechanism that fails in patients with atherosclerosisJournal of the American College of Cardiology, 1990
- Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.JCI Insight, 1990
- Occurrence of a new enzyme catalyzing the direct conversion of NG,NG-dimethyl-L-arginine to L-citrulline in ratsBiochemical and Biophysical Research Communications, 1987