Correlation between in vitro Anaphylactic Histamine Release from Tissues and Reagin Titer in Rat

Abstract

The magnitude of antigen-induced histamine release from actively sensitized rat tissues in vitro was compared with the amount of specific reagin in the serum. There was no quantitative correlation between either, suggesting that the antigen-induced histamine release from sensitized tissues might depend on the ability of sensitized target cells to release histamine. In addition, the magnitude of antigen-induced histamine release was different in each tissue of sensitized rats. This also suggested that there might be some differences in the ability of sensitized target cells in each tissue to release histamine by antigen.