Prothrombin-Complex Concentrates and Thromboses

Abstract

To the Editor: The letters of Kasper (N Engl J Med 289:160, 1973) and of Steinberg and Dreiling (N Engl J Med 289:592, 1973) reported thrombotic complications in patients with hemophilia B who had received prothrombin complex. Dr. Kasper suggested that this might be related to the presence of activated clotting factors in the prothrombin complex. The following experience emphasizes the problems related to the management of hemophilia B.On March 16, 1971, a 35-year-old man with severe hemophilia B (factor IX activity less than 1 per cent) had an inter-trochanteric fracture of the right femur. For two days he . . .