Vivax Malaria: Neglected and Not Benign
Top Cited Papers
- 1 December 2007
- journal article
- review article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 77 (6_Suppl), 79-87
- https://doi.org/10.4269/ajtmh.2007.77.79
Abstract
Plasmodium vivax threatens almost 40% of the world’s population, resulting in 132–391 million clinical infections each year. Most of these cases originate from Southeast Asia and the Western Pacific, although a significant number also occurs in Africa and South America. Although often regarded as causing a benign and self-limiting infection, there is increasing evidence that the overall burden, economic impact, and severity of disease from P. vivax have been underestimated. Malaria control strategies have had limited success and are confounded by the lack of access to reliable diagnosis, emergence of multidrug resistant isolates, the parasite’s ability to transmit early in the course of disease and relapse from dormant liver stages at varying time intervals after the initial infection. Progress in reducing the burden of disease will require improved access to reliable diagnosis and effective treatment of both blood-stage and latent parasites, and more detailed characterization of the epidemiology, morbidity, and economic impact of vivax malaria. Without these, vivax malaria will continue to be neglected by ministries of health, policy makers, researchers, and funding bodies.Keywords
This publication has 91 references indexed in Scilit:
- Mapping the global extent of malaria in 2005Trends in Parasitology, 2006
- Deployment of Early Diagnosis and Mefloquine- Artesunate Treatment of Falciparum Malaria in Thailand: The Tak Malaria InitiativePLoS Medicine, 2006
- Plasmodium vivaxMalariaEmerging Infectious Diseases, 2005
- In Vivo Assessment of Drug Efficacy against Plasmodium falciparum Malaria: Duration of Follow-UpAntimicrobial Agents and Chemotherapy, 2004
- The Microcirculation in Severe MalariaMicrocirculation, 2004
- THE IMPACT OF REPEATED MALARIA ATTACKS ON THE SCHOOL PERFORMANCE OF CHILDRENThe American Journal of Tropical Medicine and Hygiene, 2003
- Plasmodium vivax clinically resistant to chloroquine in Colombia.The American Journal of Tropical Medicine and Hygiene, 2001
- Plasmodium vivax: a cause of malnutrition in young children.QJM: An International Journal of Medicine, 1997
- Survey of resistance to chloroquine by Plasmodium vivax in IndonesiaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1996
- Spontaneous rupture of the spleen.1955