Identification of loci associated with schizophrenia by genome-wide association and follow-up
Top Cited Papers
- 30 July 2008
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 40 (9), 1053-1055
- https://doi.org/10.1038/ng.201
Abstract
Michael O'Donovan and colleagues present a genome-wide association study of schizophrenia in 479 cases and 2,937 controls, followed by replication in several cohorts. They report evidence for association for a susceptibility allele near ZNF804A. We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10−5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 × 10−4), and the overall pattern of replication was unlikely to occur by chance (P = 9 × 10−8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 × 10−7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 × 10−9).Keywords
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