ANTIBODIES CROSS-REACTIVE WITH DNA AND CARDIOLIPIN IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
- 1 January 1982
- journal article
- research article
- Vol. 50 (2), 298-302
Abstract
Using a modified solid phase radioimmunoassay (RIA), sera from 11 patients with systemic lupus erythematosus (SLE) that had high DNA binding activities were analyzed for their ability to cross-react with phospholipids. Polyspecific anti-DNA antibodies that reacted with both ssDNA [single stranded DNA] and dsDNA [double stranded DNA] had the ability to cross-react with phospholipids, especially cardiolipin. The relationship between biological false-positive serological tests for syphilis and the magnitude of serum anti-DNA antibody levels is also discussed.This publication has 14 references indexed in Scilit:
- Anti-DNA autoantibodies in (NZB X NZW)F1 mice are clonally heterogeneous, but the majority share a common idiotype.The Journal of Immunology, 1982
- Specificity of mouse hybridoma antibodies to DNAImmunology Letters, 1982
- Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids.The Journal of Experimental Medicine, 1981
- Antigen-binding diversity and idiotypic cross-reactions among hybridoma autoantibodies to DNA.The Journal of Immunology, 1981
- A quantitative, batch hydroxyapatite method for analyzing native and denatured DNA at room temperatureAnalytical Biochemistry, 1975
- The Detection of Anti-Dna and Dna/Anti-Dna ComplexesScandinavian Journal of Rheumatology, 1975
- Occurrence of antinuclear factors and immunoglobulins bound to the dermo-epidermal junction in patients with chronic biological false positive (CBFP) reactions for syphilisActa Dermato-Venereologica, 1972
- ANTIBODIES TO POLYNUCLEOTIDES IN HUMAN SERA: ANTIGENIC SPECIFICITY AND RELATION TO DISEASEThe Journal of Experimental Medicine, 1971
- Effect of 2-mercaptoethanol treatment on anticardiolipin reactivity in sera from syphilitics and false positive reactors.Sexually Transmitted Infections, 1969
- Antibodies to Native and Denatured Deoxyribonucleic Acid in Systemic Lupus Erythematosus*Journal of Clinical Investigation, 1967