Postmortem Changes in Brain Catecholamine Enzymes
- 1 January 1975
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 32 (1), 47-49
- https://doi.org/10.1001/archneur.1975.00490430069012
Abstract
Postmortem changes in the activities of tyrosine hydroxylase, dopa decarboxylase, and dopamine-β-hydroxylase were examined in various areas of rat brain. Tyrosine hydroxylase activity decreased in an exponential fashion with a half-time of two to four hours in caudate-putamen, substantia nigra, and locus ceruleus. Dopa decarboxylase activity remained within 20% of control values at five hours in these areas, but then decreased precipitously. Dopamine-β-hydroxylase activity remained within 20% of control for at least 20 hours after death.Keywords
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