Morphologische Veränderungen der Beckenkammspongiosa beim primären Hyperparathyreoidismus und ihre Bedeutung für die Diagnostik
- 1 July 1987
- journal article
- conference paper
- Published by Springer Nature in Klinische Wochenschrift
- Vol. 65 (14), 643-653
- https://doi.org/10.1007/bf01875499
Abstract
Iliac crest bone biopsy specimens of 391 patients with surgically proven primary hyperparathyroidism were investigated. In 60 unselected cases quantitative analysis of trabecular bone changes was performed. The age of the patients ranged between 12 and 85 years. The observed morphological findings were divided into four stages. In a few cases no differences from normal bone tissue could be observed. In 46% occurrence of a nonspecific increase of osteoid seams, osteoblasts, and osteoclasts was observed. Of the cases 50% showed a specific, but very often mild endosteal fibrosis. Only in 4% was there a severe fibroosteoclasia with development of so-called brown tumors. The quantitative analysis showed an increase of trabecular bone mass as well as of remodeling surfaces. But there was an overlap of up to 25% with the normal controls. The results demonstrate the influence of parathyroid hormone peptides on bone morphology. However, the investigation of a bone biopsy specimen is not generally very useful for diagnostic purposes.This publication has 13 references indexed in Scilit:
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