Rescuing the function of mutant p53
Top Cited Papers
- 1 October 2001
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 1 (1), 68-76
- https://doi.org/10.1038/35094077
Abstract
One protein — p53 — plays nemesis to most cancers by condemning damaged cells to death or quarantining them for repair. But the activity of p53 relies on its intact native conformation, which can be lost following mutation of a single nucleotide. With thousands of such mutations identified in patients, how can a future cancer drug buttress this fragile protein structure and restore the cell's natural defence?Keywords
This publication has 66 references indexed in Scilit:
- Strategies for manipulating the p53 pathway in the treatment of human cancerBiochemical Journal, 2000
- Emergence of Genetic Instability in Children Treated for LeukemiaScience, 2000
- The Hallmarks of CancerCell, 2000
- Pharmacological Rescue of Mutant p53 Conformation and FunctionScience, 1999
- A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer TherapyScience, 1999
- Regulation of p53 stability by Mdm2Nature, 1997
- The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53Cell, 1990
- p53: oncogene or anti-oncogene?Genes & Development, 1990
- Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cellsCell, 1979
- T antigen is bound to a host protein in SY40-transformed cellsNature, 1979