A Chromosome Marker for B-Cell Cancers

Abstract

To the Editor: The recent paper by Broder et al.¹ and the accompanying editorial² described new insights gained through the sophisticated investigation of a T-cell acute lymphocytic leukemia. We now present a multidisciplinary study of cells from a patient with B-cell acute lymphocytic leukemia that may also contribute to a new understanding of acute leukemia.A 33-year-old man was admitted to the University of Chicago Hospitals in August, 1977, with untreated acute lymphocytic leukemia. Table 1 summarizes the pertinent clinical and laboratory findings. Chromosomes were analyzed from 24-hour peripheral blood cultured without phytohemagglutinin and examined with both routine Giemsa and quinacrine mustard . . .