A method is proposed by which a determination of the rate at which glucose is removed from the circulation following the administration of glucose would give information regarding the ability of the animal to metabolize sugar. This method has been employed on normal and on double vagotomized dogs. Curves showing composite results are presented. If glucose is administered 20 hours preceeding the test, an increase in the ability to metabolize sugar is noted in vagotomized but not in normal animals. Chronic vagotomy does not reduce the sensitivity of the mechanism which is stimulated by the administration of glucose; the mechanism rather appears to be slightly more irritable. If these results are to be interpreted as indicating the rate of insulin secretion, they tend to show that hyperglycemia will lead to at least as great a secretion of insulin in the pancreas freed from central vagus control as in the normal Islet tissue.