Placental Transfer of Herpes Simplex Virus in Pregnant Rabbits.

Abstract
Two concentrations (101.6 and 106.6 TCID50) of herpes simplex virus were given intravenously to pregnant rabbits. The lower concentration of virus failed to cross the placenta and disappeared rapidly from the blood. The higher concentration of virus produced a viremia of 60-120 min. Death and resorption of 30% of the fetuses occurred within 2 days post-inoculation. Virus was recovered from maternal tissues as well as fetuses, fetal membranes, and fetal fluids.