Observations on the relation between sulphydryl groups and pyruvate oxidation in brain tissue

Abstract
The pyruvate - oxidase system and the pyruvate dehydrogenase component were much more sensitive to Na maleate than succinodehydrogenase. Pyruvate dehydrogenase was inactivated by cystine ester and reactivated by cysteine ester. This was explained as due to the presence of an essential[long dash]SH group in the enzyme.

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