Role of LKB1 in lung cancer development
Open Access
- 19 August 2008
- journal article
- review article
- Published by Springer Nature in British Journal of Cancer
- Vol. 99 (5), 683-688
- https://doi.org/10.1038/sj.bjc.6604515
Abstract
Three phenotypically related genetic syndromes and their lesions (LKB1, PTEN, and TSC1/2) are identified as frequently altered in lung cancer. LKB1, a kinase inactivated in 30% of lung cancers, is discussed in this review. Loss of LKB1 regulation often coincident with KRAS activation allows for unchecked growth and the metabolic capacity to accommodate the proliferation.Keywords
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