Muscarinic receptor compensation in hippocampus of Alzheimer patients
- 1 March 1983
- journal article
- research article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 56 (1), 13-19
- https://doi.org/10.1007/bf01243370
Abstract
The activity of the acetylcholine synthesizing enzyme choline acetyltransferase (ChAT) (presynaptic marker) and number of muscarine-like receptor binding sites have been measured in the hippocampus from eight individuals with senile dementia of Alzheimer type (SDAT) and ten controls. A negative correlation (r=0.80; p<0.05) was found between the ChAT activity and the number of muscarine-like receptors in the SDAT group but not in the controls. The findings might indicate an ongoing compensatory receptor mechanism as a response to changes in presynaptic cholinergic activity.Keywords
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