Effects of CE144 Administered to Pregnant Rats.

Abstract

Summary Single oral doses of 0.5 and 1.0 mc of Ce¹⁴⁴ were delivered to female rats on days 4 through 14 of gestation. High embryonic resorption rates resulted in markedly reduced numbers of young among those dosed between 4 and 9 days. Doses of 0.5 mc were damaging in this early period although less so than the higher level. Doses administered later than day 9, caused fewer embryonic deaths than those given earlier in pregnancy. The only physical defects noted in significant numbers among surviving progeny were those affecting the eyes in litters dosed on days 7, 8 or 9. No definite effect on growth rate of the offspring could be ascertained and only moderate changes in testis histology following 13- or 14-day doses. This experiment was materially aided by the technical supervision of Mr. J. E. Mitchell.