Sequence arrangement of the 5' ends of simian virus 40 16S and 19S mRNAs.
Open Access
- 1 November 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (11), 4982-4985
- https://doi.org/10.1073/pnas.74.11.4982
Abstract
EM examination of molecular hybrids between SV-40 DNA, that was cleaved with EcoRI and then digested with exonuclease III, and 16S or 19S mRNA produced late during the viral infection cycle indicated that each of these mRNA contained a 5''-terminal leader sequence that was encoded in the viral genome at about map position 0.71-0.75. Hybridization of each of these mRNA to viral DNA immobilized on nitrocellulose filters supported the EM observations.Keywords
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