Supersensitivity of cortical neurones of the rat to acetylcholine and L-glutamate following chronic morphine treatment
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 293 (1), 101-103
- https://doi.org/10.1007/bf00498877
Abstract
The effect of microelectrophoretically applied L-glutamate and acetylcholine on discharge activity of cortical neurones was studied in naive and in morphine-tolerant/dependent rats. The thresholds for increase in discharge activity elicited by these 2 putative neurotransmitters were 3 times lower in the tolerant/dependent rats than in the naive rats, indicating the development of supersensitivity.Keywords
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