CYTOTOXIC T CELL RESPONSES TO A SYNGENEIC TUMOUR: CONDITIONS FOR PRIMARY ACTIVATION IN VITRO
- 1 April 1978
- journal article
- research article
- Published by Wiley in Immunology & Cell Biology
- Vol. 56 (2), 247-251
- https://doi.org/10.1038/icb.1978.26
Abstract
Primary cytotoxic responses of DBA/2 lymph node cells to a syngeneic tumour (the mastocytoma P815) have been generated in vitro. The development of these responses is dependent on the addition of a soluble factor (CSCS) which is produced by concanavalin A-activated spleen cells. The response is mediated by T lymphocytes, can be detected at low effector to target cell ratios and is directed against P815 tumour-associated antigens.Keywords
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