CRH Defects in Alzheimer's and Other Neurologic Diseases
- 15 September 1988
- journal article
- research article
- Published by Taylor & Francis in Hospital Practice
- Vol. 23 (9), 59-71
- https://doi.org/10.1080/21548331.1988.11703535
Abstract
The demonstration of an upregulation of CRH receptors in the cerebral cortex after a decrease in cortical CRH content in Alzheimer's disease indicates the physiologic relevance of the receptor site. It is consistent with the concept that CRH acts as a neurotransmitter in normal cortical functions and that disease of this peptidergic system may be important in certain manifestations of dementia.Keywords
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