The effects of L‐arginine and NG‐monomethyl L‐arginine on the response of the rat anococcygeus muscle to NANC nerve stimulation
Open Access
- 1 December 1989
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 98 (4), 1080-1082
- https://doi.org/10.1111/j.1476-5381.1989.tb12650.x
Abstract
The effect of the competitive inhibitor of L-arginine, NG-monomethyl L-arginine (L-NMMA) on the response of the rat anococcygeus muscle to non-adrenergic, non-cholinergic (NANC) inhibitory nerve stimulation has been examined. L-NMMA causes a rise in muscle tone and inhibition of the response to nerve stimulation. The stereoisomer D-NMMA is without effect. The rise in tone and inhibition of the nerve response is reversed by L-arginine. Another analogue, L-canavanine, which is effective against L-arginine utilization in the macrophage, was without effect on the rat anococcygeus. These results provide indirect evidence for nitric oxide (NO) or a substance releasing NO as the transmitter of the NANC nerves in this tissue.This publication has 9 references indexed in Scilit:
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