STRUCTURAL BASIS FOR INHIBITION OF PROTEIN SYNTHESIS BY EMETINE AND CYCLOHEXIMIDE BASED ON AN ANALOGY BETWEEN IPECAC ALKALOIDS AND GLUTARIMIDE ANTIBIOTICS
- 1 December 1966
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 56 (6), 1867-1874
- https://doi.org/10.1073/pnas.56.6.1867
Abstract
Emetine inhibits protein synthesis in certain mammalian cells, species of Saccharomyces, and in Anemia phylitidis, a higher plant, but not in cell-free extracts prepared from Escherichia coli. Although distinctly different in chemical nature, ([long dash])-emetine and the ipecac alkaloids show configurational and con-formational similarities to ([long dash])-cycloheximide and the glutarimide antibiotics and have similar effects on protein synthesis. The results of these studies define a structural basis for the inhibition of protein synthesis and suggest a synthetic approach to new compounds of potential therapeutic and agricultural importance.This publication has 28 references indexed in Scilit:
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