PANTOYL-GAMMA-AMINOBUTYRIC ACID FACILITATES CHOLINERGIC FUNCTION IN THE CENTRAL NERVOUS-SYSTEM
- 1 January 1985
- journal article
- research article
- Vol. 232 (2), 501-506
Abstract
Pantoyl-GABA (P-GABA) administered i.p. inhibited scopolamine- and atropine-induced locomotor activities in mice, but did not inhibit methamphetamine- and apomorphine-induced locomotor activities. In radiolabeled ligand binding experiments, P-GABA did not inhibit the bindings of [3H]quinuclidinyl benzilate, [3H]spiroperidol and [3H]apomorphine to rat brain membranes, but inhibited that of [3H]muscimol. GABA and P-GABA enhanced K+ (25 mM)-induced release of [3H]acetylcholine from slices of the cerebral cortex and hippocampus dose-dependently, and their effects were antagonized by bicuculline but not by tetrodotoxin. P-GABA apparently binds to GABA receptors causing enhanced cholinergic neurotransmission in the CNS. The results are discussed in relation to the clinical use of P-GABA in treatment of Alzheimer''s disease and senile dementia of the Alzheimer type.This publication has 21 references indexed in Scilit:
- Effects of dopaminergic agonists and antagonists on [3H]apomorphine binding to striatal membranes: sulpiride lack of interactions with positive cooperative [3H]apomorphine bindingBrain Research, 1980
- The effect of some putative neurotransmitters on the release of 5-hydroxytryptamine and γ-aminobutyric acid from slices of the rat midbrain raphe areaNeuroscience, 1979
- Neurotransmitter-related enzymes in senile dementia of the alzheimer typeBrain Research, 1979
- Lisurioe inhibits 3H-spiroperidol binding to membranes isolated from striatumNeuropharmacology, 1978
- Neurotransmitter enzyme abnormalities in senile dementiaJournal of the Neurological Sciences, 1977
- NEOCORTICAL CHOLINERGIC NEURONS IN ELDERLY PEOPLEThe Lancet, 1977
- Regional changes in the rate of turnover of acetylcholine in rat brain following diazepam or muscimolNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1976
- SODIUM‐DEPENDENT HIGH AFFINITY CHOLINE UPTAKE: A REGULATORY STEP IN THE SYNTHESIS OF ACETYLCHOLINEJournal of Neurochemistry, 1976
- Chemical and enzymatic synthesis of γ-pantothenateBiochimica et Biophysica Acta (BBA) - General Subjects, 1964
- A study of the synthesis of γ-pantothenate by neurosporaBiochimica et Biophysica Acta (BBA) - General Subjects, 1964