Diurnal Variations in Tissue Glycogen and Liver Weight of Meal-fed Rats
- 1 December 1967
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 93 (4), 546-554
- https://doi.org/10.1093/jn/93.4.546
Abstract
The studies reported were designed 1) to describe the diurnal variations in tissue glycogen levels in meal-fed rats (animals having access to food for a single, daily, 2-hour meal), and 2) to compare the tissue glycogen storage capacity of meal-fed and nibbling (ad libitum-fed) rats. Rats trained to a meal-eating schedule and nibbling rats were maintained without food for 22 hours and then allowed access to food for 2 hours. The rats were killed at various times after the initiation of the meal, and liver, diaphragm and adipose tissue glycogen content was determined. Fasting liver glycogen levels were higher in meal-fed rats, but glycogen accumulated at the same rate in livers of meal-fed and nibbling rats for up to 8 hours after the start of the meal. Liver glycogen then decreased linearly from 8 to 22 hours. Meal-fed rats had a greater capacity to accumulate glycogen in diaphragm muscle and adipose tissue than nibbling rats. In meal-fed animals glycogen accumulated in diaphragm and adipose tissue for 8 hours, fell sharply between 8 and 10 hours after the initiation of the meal, and decreased more slowly from 10 to 22 hours. Liver weight increased significantly upon meal ingestion in both meal-fed and nibbling rats. Water accounted for about 66% of the increase and glycogen was responsible for the remainder. It was estimated that about 30% of the calories stored during and following the daily meal in meal-fed rats were in the form of glycogen. The data are discussed in terms of the importance of glycogen as a storage form of energy for the meal-fed animal.Keywords
This publication has 18 references indexed in Scilit:
- Estimation of glycogen in small amounts of tissueAnalytical Biochemistry, 1965
- Food Restriction and Lipogenesis in the Rat.Experimental Biology and Medicine, 1964
- Glucose Metabolism in the Rat During Starvation and Refeeding Following Starvation.Experimental Biology and Medicine, 1964
- Lipid Changes in Plasma, Alpha Lipoproteins, Liver and Aorta of Chicks Fed Different FatsExperimental Biology and Medicine, 1963
- METABOLIC ADAPTATIONS TO A “STUFF AND STARVE” FEEDING PROGRAM. I. STUDIES OF ADIPOSE TISSUE AND LIVER GLYCOGEN IN RATS LIMITED TO A SHORT DAILY FEEDING PERIOD*JCI Insight, 1962
- Microdetermination of Long-chain Fatty Acids in Plasma and TissuesJournal of Biological Chemistry, 1960
- Conversion of glucose to glycogen after ingestion of a high-carbohydrate dietAmerican Journal of Physiology-Legacy Content, 1960
- ROLE OF RATE OF INGESTION OF DIET ON REGULATION OF INTERMEDIARY METABOLISM (MEAL EATING VS NIBBLING)1960
- Effects of Antecedent Food Intake Pattern on Hepatic LipogenesisAmerican Journal of Physiology-Legacy Content, 1958
- THE COMPOSITION OF THE GAINS IN WEIGHT AND THE UTILIZATION OF FOOD ENERGY IN GROWING RATSAmerican Journal of Physiology-Legacy Content, 1926