Specific epidermal growth factor receptors on porcine thyroid cell membranes
- 7 March 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 153 (1), 88-92
- https://doi.org/10.1016/0014-5793(83)80124-0
Abstract
Specific saturable receptors for epidermal growth factor (EGF) of high affinity (K a 1.7 × 109 M−1) have been demonstrated on porcine thyroid membranes. Optimal conditions for EGF binding have been determined. TSH and other peptide hormones do not inhibit the binding of 125I‐EGF and EGF does not inhibit 125I‐TSH binding to thyroid membranes. The results suggest that EGF may be involved in the regulation of thyroid follicular cell growth and function.Keywords
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