LACK OF EFFECT OF PROLACTIN SUPPRESSION ON PLASMA DEHYDROEPIANDROSTERONE SULPHATE

Abstract

In 12 patients with hyperprolactinemia, treatment which reduced plasma prolactin from a mean of 531 .mu.g/l (range 68-3500 .mu.g/l) to 8.3 .mu.g/l (0-27 .mu.g/l), caused no significant change in plasma dehydroepiandrosterone sulfate (DHA-SO4). Pre-treatment levels of DHA-SO4 were within the normal range in 11 of 12 cases. Claims that prolactin excess is associated with an increase in circulating DHA-SO4 are not supported.