Clinical Aspects of IgE Myeloma

Abstract

A 60-year-old man with signs of anemia, thrombocytopenia and hyperviscosity was found to have multiple myeloma. The abnormal serum globulin component was identified as IgE lambda protein, which when tested with antiserum to normal human IgE, gave a band of identity with serum from the only previously described case of IgE myeloma. IgE was demonstrated in the myeloma cells of the bone marrow and peripheral blood by immunofluorescence. This patient, in addition to one described in a previous report, had on initial examination plasma-cell leukemia, a lambda myeloma protein and absence of bony lesions.