Spinal cord injury in rat
Top Cited Papers
- 11 September 2000
- journal article
- regeneration and-transplantation
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 11 (13), 3001-3005
- https://doi.org/10.1097/00001756-200009110-00035
Abstract
We tested the hypothesis that transplantation of bone marrow stromal cells (MSCs) into the spinal cord after a contusion injury promotes functional outcome. Rats (n = 31) were subjected to a weight driven implant injury. MSCs or phosphate buffered saline was injected into the spinal cord I week after injury. Sections of tissue were analyzed by double-labeled immunohistochemistry for MSC identification. Functional outcome measurements using the Basso-Beattie-Bresnehan score were performed weekly to 5 weeks post-injury. The data indicate significant improvement in functional outcome in animals treated with MSC transplantation compared to control animals. Scattered cells derived from MSCs expressed neural protein markers. These data suggest that transplantation of MSCs may have a therapeutic role after spinal cord injury.Keywords
This publication has 10 references indexed in Scilit:
- Active forces in hearingTrends in Neurosciences, 2000
- Intracerebral transplantation of bone marrow with BDNF after MCAo in ratNeuropharmacology, 2000
- Functional regeneration of sensory axons into the adult spinal cordNature, 2000
- Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brainsProceedings of the National Academy of Sciences, 1999
- Temporal profile of nestin expression after focal cerebral ischemia in adult ratBrain Research, 1999
- Grafts of Fibroblasts Genetically Modified to Secrete Ngf, Bdnf, Nt-3, or Basic Fgf Elicit Differential Responses in the Adult Spinal CordCell Transplantation, 1996
- The hematopoietic cytokine, colony‐stimulating factor 1, is also a growth factor in the CNS: Congenital absence of CSF‐1 in mice results in abnormal microglial response and increased neuron vulnerability to injuryInternational Journal of Developmental Neuroscience, 1995
- A Sensitive and Reliable Locomotor Rating Scale for Open Field Testing in RatsJournal of Neurotrauma, 1995
- Monoclonal Antibody to 5-Bromo- and 5-Iododeoxyuridine: A New Reagent for Detection of DNA ReplicationScience, 1982
- Fine Structure of MedulloepitheliomaJournal of Neuropathology and Experimental Neurology, 1977