In a review of 213 cases of acromegaly it was found that 10 patients had complained of a periodic pain in the hands and 8 had complained of a similar disturbance in the feet. Usually the discomfort had been associated with paresthesias and had been present in both hands and feet. Different observers have reported that a more or less general increase in connective tissue occurs in cases of acromegaly, and this has also been observed to occur in the peripheral nerves. These observations led to the inference that the pain and paresthesia are the result of interstitial neuritis. One might ask, however, since these phenomena are usually transitory, whether they may not be of vascular origin. The enlargement of the hands and feet that takes place in acromegaly may justifiably lead to the assumption that there is a concomitant increase in the circulation which may not be unattended by