CLINICAL STUDIES OF INDU CTION AGENTS XI: THE INFLUENCE OF SOME INTRAVENOUS ANAESTHETICS ON THE RESPIRATORY EFFECTS AND SEQUELAE OF SUXAMETHONIUM

Abstract

Suxamethonium 25 mg was injected intravenously after induction of anaesthesia with equipotent doses of thiopentone, thialbarbitone, methohexitone, FBA.1420 and G.29.505. The duration of apnoea and of respiratory depression was measured and found to be significantly greater after the two eugenol derivatives than after the barbiturates. The incidence of postoperative muscle pains was found to be significantly lower after methohexitone, and after the eugenol derivatives, than after thiopentone and thialbarbitone. The possible mechanisms of these findings may include a direct action of the eugenol derivatives on voluntary muscle.