The life span of naive alpha/beta T cells in secondary lymphoid organs.
Open Access
- 1 April 1993
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 177 (4), 891-896
- https://doi.org/10.1084/jem.177.4.891
Abstract
We have determined the life span of naive CD4-8+ T cells in T cell receptor transgenic mice. We find that such cells do not divide in secondary lymphoid organs in both normal euthymic mice and T cell-deficient mice. By both continuous labeling and by chasing pulse-labeled cells, we find that the minimum life span of the naive T cells is in the order of 8 wk.Keywords
This publication has 23 references indexed in Scilit:
- An unusual lineage of alpha/beta T cells that contains autoreactive cells.The Journal of Experimental Medicine, 1991
- Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype.The Journal of Experimental Medicine, 1991
- Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic miceCell, 1991
- Peripheral Selection of the T Cell RepertoireScience, 1991
- Interconversion of CD45R subsets of CD4 T cells in vivoNature, 1990
- Limiting dilution analysis of CD45Rhi and CD45Rlo T cells: Further evidence that CD45Rlo cells are memory cellsCellular Immunology, 1990
- Maintenance of B-cell memory by long-lived cells generated from proliferating precursorsNature, 1990
- The Cellular Basis of T-Cell MemoryAnnual Review of Immunology, 1989
- Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cellsNature, 1988
- Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytesNature, 1988