THE EFFECT OF SALTS ON THE DIABETES INSIPIDUS FOLLOWING POSTHYPOPHYSECTOMY IN THE RAT1

Abstract

NaCl, given in drinking solns., causes extreme aggravation of the diabetes insipidus following removal of post. hypophysis in rats. In concentrated solns., it may cause death. It also prevents spontaneous recovery from operative diabetes insipidus seen in rats. Pituitrin prevents these saline aggravations. Mammalian Ringer''s soln. and NaHCO3 are similarly diuretic. Na2SO4, Na citrate, KCl and CaCl2 exert no diuretic effects on the diabetic rats beyond their effects on the normal rat.