Failure of sodium- and calcium-deficient rats to acquire conditioned taste aversions to the object of their specific hunger.

Abstract

Attempts were made to condition taste aversions to the objects of two mineral-specific hungers. Both the innate preference of adrenalectomized rats for sodium and the learned preference of parathyroidectomized rats for calcium were studied. None of the sodium-deficient rats poisoned after drinking sodium chloride (NaCl) reached a taste-avoidance criterion, even after nine pairings of salt ingestion with aversive lithium chloride injections. Six of 11 calcium-deficient rats did not meet the salt-avoidance criterion after 10 pairings. Nondeficient control subjects learned to avoid these salt solutions completely after an average of only three such pairings. Besides unmasking a surprising degree of similarity between the learned and innate specific hungers studied, the results clearly demonstrate a powerful influence of physiological need on aversion conditioning.