Alloxan Diabetes in Rabbits. Production of Hypercholesterolemia, Hyperlipemia and Adrenal Cortical Lesions

Abstract

A transient period of hypercholesterolemia and hyperlipemia may accompany the early stage of severe diabetes in rabbits following the injn. of alloxan. A dosage of 50 mg/kg failed to cause hyperlipemia or hypercholesterolemia, 100 mg/kg produced it in 1 of 3 rabbits, while 125 mg/kg was effective in 29 of 32 animals. Lesions were found in the adrenal cortices of 12 of 25 animals dying after receiving 125 mg/kg of alloxan.