Human B Cell Function in a Polyclonally Induced Plaque Forming Cell System. Cell Triggering and Immunoregulation
- 1 June 1979
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 45 (1), 93-116
- https://doi.org/10.1111/j.1600-065x.1979.tb00274.x
Abstract
The use of a sensitive PFC assay against a specific antigenic determinant (SRBC) following polyclonal triggering of human lymphocytes has provided a unique insight into the complex mechanisms of triggering of human B cells. The system is under the strict regulation of a delicate balance between helper and suppressor influences reflecting in certain circumstances the activity of distinct subsets of immunoregulatory cells. Lymphoid cells in certain diseases characterized by disordered immunoregulation, when as system, may in effect be manifesting an abnormal expression of immunoregulatory mechanisms operable in normal immune responses. In vivo activation of lymphoid cells by PBAs may have an important role in disease states as well as in the subsequent in vitro expression of B cell function. Furthermore, it is quite possible that under certain circumstances some B cell responses which appear to be purely antigen-specific may be reflections of synergy between PBA substances and specific antigen. The use of PBAs as probes and sensitive PVC systems as assays has already proven fruitful in the dissection of the complex mechanisms of nonspecific B cell triggering in man and may indeed ultimately lead to an understanding of the mechanisms of specificity of immune reactivity.Keywords
This publication has 44 references indexed in Scilit:
- Glucocorticoids Administered In Vivo Inhibit Human Suppressor T Lymphocyte Function and Diminish B Lymphocyte Responsiveness in In Vitro Immunoglobulin SynthesisJCI Insight, 1978
- Impaired immunoglobulin synthesis by peripheral blood lymphocytes in systemic lupus erythematosusArthritis & Rheumatism, 1978
- Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG.The Journal of Experimental Medicine, 1977
- Rheumatoid factor-producing cells detected by direct hemolytic plaque assay.JCI Insight, 1976
- Heterogeneity of B Cells: Direct Evidence of Selective Triggering of Distinct Subpopulations by Polyclonal ActivatorsScandinavian Journal of Immunology, 1976
- Responsiveness of Lymphoid Precursors to Polyclonal B-Cell ActivatorsScandinavian Journal of Immunology, 1975
- ROLE OF SUPPRESSOR T CELLS IN PATHOGENESIS OF COMMON VARIABLE HYPOGAMMAGLOBULINÆMIAThe Lancet, 1974
- Differentiation of B Cells: Sequential Appearance of Responsiveness to Polyclonal ActivatorsScandinavian Journal of Immunology, 1974
- Adjuvant effects on poly I poly C in New Zealand miceArthritis & Rheumatism, 1972
- Plaque Formation in Agar by Single Antibody-Producing CellsScience, 1963