DNA sequence determinants of CAP-induced bending and protein binding affinity
- 1 June 1988
- journal article
- Published by Springer Nature in Nature
- Vol. 333 (6176), 824-829
- https://doi.org/10.1038/333824a0
Abstract
The sites of DNA bending induced by binding catabolite activator protein are identified and shown to coincide with positions where DNA grooves face the protein. The bendability of DNA with different sequences at these bend centres parallels the bending preference of the sequences in nucleosomal DNA. Anisotropic DNA bendability significantly affects the structure and strength of regulatory protein-DNA complexes.Keywords
This publication has 40 references indexed in Scilit:
- DNA bend direction by phase sensitive detectionNature, 1987
- Sequence-specific positioning of core histones on an 860 base-pair DNAJournal of Molecular Biology, 1987
- Direct Evidence for DNA Bending at the Lambda Replication OriginScience, 1987
- Principles of sequence-dependent flexure of DNAJournal of Molecular Biology, 1986
- Sequence periodicities in chicken nucleosome core DNAJournal of Molecular Biology, 1986
- Bending and flexibility of kinetoplast DNABiochemistry, 1986
- DNA bending and its relation to nucleosome positioningJournal of Molecular Biology, 1985
- Conformational changes in a replication origin induced by an initiator proteinCell, 1985
- Curved DNCritical Reviews in Biochemistry, 1985
- Mechanism of CRP-cAMP activation of lac operon transcription initiation activation of the P1 promoterJournal of Molecular Biology, 1984